How long it took to develop other vaccines in history
New Fronts Are Opening In The War Against Malaria
In the shade of a tree outside a clinic in Wakiso near Kampala, Uganda's capital, Hadijah Mirembe watches over her nine-month-old son. She has been here for two days, ever since his temperature soared. He has malaria, she explains, as his chest rises and falls rapidly in his sleep. So does she. These days, even when she sleeps under a net, she often wakes to find a satisfied mosquito that has snuck inside.
Millions of parents in Africa know the worry of caring for a child with malaria. Many know the grief of losing one. But two new vaccines give hope. The first, rts,s/as01, has been tried on nearly 2m children in Kenya, Ghana and Malawi since 2019, and is being used in seven more countries this year. The second, r21/Matrix-m, which is being made in larger volumes at less than half the price, started shipping on May 24th to the Central African Republic.
Mosquito Species From Asia Pose Growing Risk To Africa's Anti-malaria Efforts
Mosquitoes cling to the inside of a jar loaded with repellent during a test as part of a tour of the Center for Disease Control laboratory, Thursday, April 4, 2024, in Fort Collins, Colo.Photo Credit: AP
The spread of the mosquito species Anopheles stephensi across Africa poses a significant problem to a continent already heavily burdened by malaria. Most – 90% – of the world's malaria deaths are on the continent.
Researchers from Djibouti reported the presence of An. Stephensi in the Horn of Africa in 2012. Until then it had not been found in Africa although it was known to be widespread in Southeast Asia and parts of the Arabian Peninsula. By 2017 it had spread through the Horn of Africa, reaching Ethiopia, Somalia and Sudan.
The spread of An. Stephensi is particularly concerning because the mosquito has a number of characteristics that make it difficult to control. This species can thrive in urban areas and likes being near humans. They lay their eggs in any available water source – such as water containers, abandoned tyres and flowerpots – and their eggs can survive being dry for a long period of time. In addition, An. Stephensi feeds on its vertebrate host both indoors and outdoors. This reduces the impact of commonly used vector control methods such as insecticide-treated nets and indoor residual spraying.
The invasion of this urban mosquito into Africa threatens the malaria elimination aspirations of the continent, particularly as 42.5% of Africa's population now live in urban areas.
As a result, national malaria control programmes have increased surveillance efforts in urban areas to enable early detection and control. Countries have also run awareness campaigns to encourage communities to reduce potential breeding sites.
The species has not yet been detected in southern Africa. Nevertheless the South African national malaria control programme, with the support of the National Institute for Communicable Diseases, is increasing surveillance activities in areas where this species may occur.
Invasive speciesMany epidemics and pandemics have been driven by pathogens, hosts and vectors invading new areas. These include the Black Death in 14th century Europe, caused by the invasion of rats carrying fleas infected with the plague.
The Asian tiger mosquito (Aedes albopictus) and the yellow fever mosquito (Aedes aegypti) both carry dangerous diseases such as dengue, yellow fever and Zika. The spread of these mosquito species into North America and Europe during the 1970s and 1980s was associated with large increases in these diseases.
While Aedes mosquitoes transmit viral diseases, Anopheles mosquitoes transmit malaria. Of the 500 Anopheles species, only 30-40 can spread malaria. Common species that transmit malaria in Africa are Anopheles gambiae, An. Arabiensis and An. Funestus.
Anopheles gambiae is one of the most effective malaria vectors in the world. It invaded South America in the 1930s. This species rapidly established itself in Brazil, causing a malaria epidemic with an estimated fatality rate of 13%. Anopheles gambiae was eventually eliminated from Brazil in the 1940s after a highly co-ordinated and resource-intensive effort.
Anopheles stephensi is a malaria vector native to South Asia. It transmits both Plasmodium falciparum and P. Vivax. It rapidly adapts to changes in the environment and is found in both rural and urban areas. This is different from African malaria vectors, which are typically found in rural areas.
Controlling this invasive mosquito is very challenging. It is difficult to find, particularly in urban areas, and is resistant to a number of insecticides. Although there are no specific programmes to eliminate this species from Africa, the affected countries are implementing a range of control measures.
Urgent actionThe presence of An. Stephensi in Africa is a call to action to all interested in controlling and eliminating malaria.
It is imperative that entomological surveillance (the search for and biological investigation of insects, including malaria vectors) is strengthened across the continent. New information about the species must be shared promptly to ensure malaria control programmes use the correct methods to prevent it from spreading further into the continent.
And an integrated approach to vector control is urgently required. Vector control measures, adapted to local conditions, are key to preventing the spread of An. Stephensi. National malaria control programmes cannot rely solely on insecticides to control this mosquito. They must invest in novel vector control methods that target outdoor-biting mosquitoes.
Governments must also invest in educating communities on the appropriate methods for storing water as well as eliminating potential breeding sources. South America has implemented strong policies to reduce breeding areas for Aedes mosquitoes. Similar approaches in Africa would reduce the presence of An. Stephensi, as well as of Aedes mosquitoes, which carry many dreaded diseases including dengue, yellow fever, chikungunya and Zika.
Crucially, a healthy population without circulating parasites is key to a malaria-free future. Integrating clinical care, vector control and community awareness of the disease is the best way to ensure a malaria-free future for the continent.
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Djibouti Looks To Genetically Engineered Mosquitoes To Quell Urban Malaria Wave
Djibouti looks to genetically engineered mosquitoes to quell urban malaria wave
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